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EVI5 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O60447 |
| Other Accession | P97366 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 92949 Da |
| Antigen Region | 191-220 aa |
| Gene ID | 7813 |
|---|---|
| Other Names | Ecotropic viral integration site 5 protein homolog, EVI-5, Neuroblastoma stage 4S gene protein, EVI5, NB4S |
| Target/Specificity | This EVI5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-220 amino acids from the N-terminal region of human EVI5. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | EVI5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EVI5 |
|---|---|
| Synonyms | NB4S |
| Function | Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis. |
| Cellular Location | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle Note=Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis |
| Tissue Location | Expressed in various cell lines (at protein level). Expressed in a wide range of tissues including brain and adrenal |
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Provided below are standard protocols that you may find useful for product applications.
Background
EVI5 is a novel centrosomal protein with a complex expression pattern and subcellular localization, possibly involved in centrosome stability and dynamics. It may act as an oncogene.
References
Jacob,B., et.al., Blood 115 (8), 1610-1620 (2010)
Hoppenbrouwers,I.A., et.al., J. Hum. Genet. 54 (11), 676-680 (2009)
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