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MALD2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q8N4S9 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 64168 Da |
| Antigen Region | 386-415 aa |
| Gene ID | 153562 |
|---|---|
| Other Names | MARVEL domain-containing protein 2, Tricellulin, MARVELD2, TRIC |
| Target/Specificity | This MALD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 386-415 amino acids from the C-terminal region of human MALD2. |
| Dilution | IHC-P~~1:50~100 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MALD2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MARVELD2 (HGNC:26401) |
|---|---|
| Synonyms | TRIC |
| Function | Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, tight junction. Note=Located at tricellular contacts. |
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Provided below are standard protocols that you may find useful for product applications.
Background
MALD2 plays a role in the formation of the epithelial barriers. The separation of the endolymphatic and perilymphatic spaces of the organ of Corti from one another by epithelial barriers is required for normal hearing.
References
Tam,S., et.al., Nat. Struct. Mol. Biol. 16 (12), 1279-1285 (2009)
Krug,S.M., et.al., Mol. Biol. Cell 20 (16), 3713-3724 (2009)
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