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Kir2.1 Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC |
|---|---|
| Primary Accession | P63252 |
| Reactivity | Rat |
| Clonality | Monoclonal |
| Other Names | KCNJ2; ATFB9; HHBIRK1; IRK1; KIR2.1; LQT7; HIRK1; IRK-1; HHIRK1; SQT3; |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 48288 Da |
| Dilution | WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human Kir2.1 |
| Description | Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | KCNJ2 |
|---|---|
| Synonyms | IRK1 |
| Function | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it (PubMed:36149965, PubMed:7590287, PubMed:9490857). Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages (PubMed:7590287, PubMed:7696590). The inward rectification is mainly due to the blockage of outward current by internal magnesium (PubMed:9490857). Can be blocked by extracellular barium or cesium (PubMed:7590287, PubMed:7696590). Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues (PubMed:7590287, PubMed:7696590, PubMed:7840300). |
| Cellular Location | Cell membrane; Multi-pass membrane protein Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:Q64273} |
| Tissue Location | Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain |
Research Areas
Citations (0)
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Application Protocols
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$ 195.00
$ 385.00
Cat# AP92549
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