|Application ||FC, WB, E|
|Calculated MW||61623 Da|
|Antigen Region||350-377 aa|
|Other Names||Gamma-aminobutyric acid receptor subunit alpha-4, GABA(A) receptor subunit alpha-4, GABRA4|
|Target/Specificity||This GABRA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 350-377 amino acids from the Central region of human GABRA4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GABRA4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
GABRA4 is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor.
Guilmatre,A., et.al., Arch. Gen. Psychiatry 66 (9), 947-956 (2009)
Maldonado-Aviles,J.G., et.al., Am J Psychiatry 166 (4), 450-459 (2009)
Agrawal,A., et.al., Addiction 104 (3), 471-477 (2009)
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