TSPAN2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, WB, E |
---|---|
Primary Accession | O60636 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 24148 Da |
Antigen Region | 109-137 aa |
Gene ID | 10100 |
---|---|
Other Names | Tetraspanin-2, Tspan-2, Tetraspan NET-3, TSPAN2 |
Target/Specificity | This TSPAN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-137 amino acids from the Central region of human TSPAN2. |
Dilution | WB~~1:1000 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | TSPAN2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TSPAN2 |
---|---|
Function | May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath. |
Cellular Location | Membrane; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
TSPAN2 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.
References
Davila,S., et.al., Genes Immun. 11 (3), 232-238 (2010)
Hemler,M.E. J. Cell Biol. 155 (7), 1103-1107 (2001)
Berditchevski,F. J. Cell. Sci. 114 (PT 23), 4143-4151 (2001)
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