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AFM Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - AFM Antibody (N-term) AP9445a
    Western blot analysis of AFM Antibody (N-term) (Cat. #AP9445a) in HepG2 cell line lysates (35ug/lane). AFM (arrow) was detected using the purified Pab.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P43652
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 69069 Da
Antigen Region 49-76 aa
Additional Information
Gene ID 173
Other Names Afamin, Alpha-albumin, Alpha-Alb, AFM, ALB2, ALBA
Target/Specificity This AFM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-76 amino acids from the N-terminal region of human AFM.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAFM Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AFM
Synonyms ALB2, ALBA
Function Functions as a carrier for hydrophobic molecules in body fluids (Probable). Essential for the solubility and activity of lipidated Wnt family members, including WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B (PubMed:26902720). Binds vitamin E (PubMed:15952736, PubMed:12463752). May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient (PubMed:15952736). May be involved in the transport of vitamin E across the blood-brain barrier (PubMed:19046407).
Cellular Location Secreted
Tissue Location High level detected in plasma but also in extravascular fluids such as follicular and cerebrospinal fluids (at protein level).
Research Areas
Citations (0)
citation

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Background

AFM is a member of the albumin gene family, which is comprised of four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally-related serum transport proteins that are known to be evolutionarily related. The protein encoded by this gene is regulated developmentally, expressed in the liver and secreted into the bloodstream.

References

Dieplinger, H., et al. Cancer Epidemiol. Biomarkers Prev. 18(4):1127-1133(2009)
Kratzer, I., et al. J. Neurochem. 108(3):707-718(2009)
Ramachandran, P., et al. J. Proteome Res. 5(6):1493-1503(2006)
Hu, Y., et al. Mol. Cell Proteomics 4(12):2000-2009(2005)
Liu, T., et al. J. Proteome Res. 4(6):2070-2080(2005)
Bunkenborg, J., et al. Proteomics 4(2):454-465(2004)

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$ 182.50
$ 70.00
Cat# AP9445a
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