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DGCR2 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - DGCR2 Antibody (Center) AP9451c
    Western blot analysis of DGCR2 Antibody (Center) (Cat. #AP9451c) in mouse liver tissue lysates (35ug/lane). DGCR2 (arrow) was detected using the purified Pab.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P98153
Other Accession P98154
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 265-292 aa
Additional Information
Other Names Integral membrane protein DGCR2/IDD, DGCR2, IDD, KIAA0163
Target/Specificity This DGCR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-292 amino acids from the Central region of human DGCR2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDGCR2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DGCR2
Synonyms IDD, KIAA0163
Function Putative adhesion receptor, that could be involved in cell- cell or cell-matrix interactions required for normal cell differentiation and migration.
Cellular Location Membrane; Single-pass type I membrane protein.
Tissue Location Predominantly expressed in brain, heart, lung and fetal kidney. Low levels in liver and adult kidney EMBL; X84076; CAA58883.1; -; mRNA EMBL; X83545; CAA58536.1; -; mRNA EMBL; L46352; AAB59561.1; -; mRNA EMBL; D79985; BAA11480.1; -; mRNA EMBL; FJ032369; ACI00235.1; -; mRNA EMBL; AK291670; BAF84359.1; -; mRNA EMBL; AK304382; BAH14171.1; -; mRNA EMBL; CR456433; CAG30319.1; -; mRNA EMBL; AC000095; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AC004461; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AC004462; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AC004471; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471176; EAX03061.1; -; Genomic_DNA EMBL; BC032430; AAH32430.1; -; mRNA CCDS; CCDS33598.1; -. [P98153-1] CCDS; CCDS54496.1; -. [P98153-2] PIR; I37579; I37579 PIR; I84463; I84463 RefSeq; NP_001167004.1; NM_001173533.1. [P98153-2] RefSeq; NP_001167005.1; NM_001173534.1 RefSeq; NP_005128.1; NM_005137.2. [P98153-1] SMR; P98153; - BioGRID; 115314; 11 IntAct; P98153; 4 MINT; P98153; - STRING; 9606.ENSP00000263196; - GlyConnect; 1404; 1 N-Linked glycan (1 site) GlyGen; P98153; 2 sites iPTMnet; P98153; - PhosphoSitePlus; P98153; - BioMuta; DGCR2; - DMDM; 1708396; - jPOST; P98153; - MassIVE; P98153; - MaxQB; P98153; - PaxDb; P98153; - PeptideAtlas; P98153; - PRIDE; P98153; - ProteomicsDB; 57792; -. [P98153-1] ProteomicsDB; 57793; -. [P98153-2] Antibodypedia; 7402; 148 antibodies DNASU; 9993; - Ensembl; ENST00000263196; ENSP00000263196; ENSG00000070413. [P98153-1] Ensembl; ENST00000537045; ENSP00000440062; ENSG00000070413. [P98153-2] GeneID; 9993; - KEGG; hsa:9993; - UCSC; uc062bkk.1; human. [P98153-1] CTD; 9993; - DisGeNET; 9993; - EuPathDB; HostDB:ENSG00000070413.18; - GeneCards; DGCR2; - GeneReviews; DGCR2; - HGNC; HGNC:2845; DGCR2 HPA; ENSG00000070413; Low tissue specificity MalaCards; DGCR2; - MIM; 600594; gene neXtProt; NX_P98153; - OpenTargets; ENSG00000070413; - PharmGKB; PA27307; - eggNOG; KOG1215; Eukaryota GeneTree; ENSGT00390000017655; - HOGENOM; CLU_036610_0_0_1; - InParanoid; P98153; - PhylomeDB; P98153; - TreeFam; TF330997; - PathwayCommons; P98153; - BioGRID-ORCS; 9993; 6 hits in 869 CRISPR screens ChiTaRS; DGCR2; human GeneWiki; DGCR2; - GenomeRNAi; 9993; - Pharos; P98153; Tbio PRO; PR:P98153; - Proteomes; UP000005640; Chromosome 22 RNAct; P98153; protein Bgee; ENSG00000070413; Expressed in amniotic fluid and 253 other tissues ExpressionAtlas; P98153; baseline and differential Genevisible; P98153; HS GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0016020; C:membrane; IBA:GO_Central GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW GO; GO:0009887; P:animal organ morphogenesis; TAS:ProtInc GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW GO; GO:0050890; P:cognition; IMP:UniProtKB CDD; cd03599; CLECT_DGCR2_like; 1 CDD; cd00112; LDLa; 1 Gene3D; 3.10.100.10; -; 1 Gene3D; 4.10.400.10; -; 1 InterPro; IPR001304; C-type_lectin-like InterPro; IPR016186; C-type_lectin-like/link_sf InterPro; IPR016187; CTDL_fold InterPro; IPR034010; DGCR2-like_CTLD InterPro; IPR042378; IDD InterPro; IPR036055; LDL_receptor-like_sf InterPro; IPR023415; LDLR_class-A_CS InterPro; IPR002172; LDrepeatLR_classA_rpt InterPro; IPR001007; VWF_dom PANTHER; PTHR15256; PTHR15256; 1 Pfam; PF00057; Ldl_recept_a; 1 Pfam; PF00059; Lectin_C; 1 SMART; SM00034; CLECT; 1 SMART; SM00192; LDLa; 1 SMART; SM00214; VWC; 1 SUPFAM; SSF56436; SSF56436; 1 SUPFAM; SSF57424; SSF57424; 1 PROSITE; PS50041; C_TYPE_LECTIN_2; 1 PROSITE; PS01209; LDLRA_1; 1 PROSITE; PS50068; LDLRA_2; 1 PROSITE; PS01208; VWFC_1; 1 1: Evidence at protein level; Alternative splicing; Cell adhesion; Disulfide bond; Glycoprotein; Lectin; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix SIGNAL 1..20 /evidence="ECO:0000255" CHAIN 21..550 /note="Integral membrane protein DGCR2/IDD" /id="PRO_0000021484" TOPO_DOM 21..349 /note="Extracellular" /evidence="ECO:0000255" TRANSMEM 350..368 /note="Helical" /evidence="ECO:0000255" TOPO_DOM 369..550 /note="Cytoplasmic" /evidence="ECO:0000255" DOMAIN 28..68 /note="LDL-receptor class A" /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" DOMAIN 115..241 /note="C-type lectin" /evidence="ECO:0000255|PROSITE-ProRule:PRU00040" DOMAIN 270..333 /note="VWFC" MOD_RES 381 /note="Phosphoserine" /evidence="ECO:0000244|PubMed:23186163" CARBOHYD 149 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000255" CARBOHYD 196 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000255" DISULFID 30..44 /evidence="ECO:0000250" DISULFID 37..57 /evidence="ECO:0000250" DISULFID 51..66 /evidence="ECO:0000250" DISULFID 145..265 /evidence="ECO:0000250" DISULFID 233..257 /evidence="ECO:0000250" VAR_SEQ 26..66 /note="Missing (in isoform 2)" /evidence="ECO:0000303|PubMed:14702039" /id="VSP_042886" VAR_SEQ 315..327 /note="QGCQQYRKDPKEC -> HGCSPLSCTARAT (in isoform 3)" /evidence="ECO:0000303|PubMed:19906316" /id="VSP_057188" VAR_SEQ 328..550 /note="Missing (in isoform 3)" /evidence="ECO:0000303|PubMed:19906316" /id="VSP_057189" VARIANT 473 /note="V -> A (in dbSNP:rs2072123)" /evidence="ECO:0000269|PubMed:7655455" /id="VAR_020046" SEQUENCE 550 AA; 60811 MW; 770204F2F36A8AAC CRC64; MVPKADSGAF LLLFLLVLTV TEPLRPELRC NPGQFACRSG TIQCIPLPWQ CDGWATCEDE SDEANCPEVT GEVRPHHGKE AVDPRQGRAR GGDPSHFHAV NVAQPVRFSS FLGKCPTGWH HYEGTASCYR VYLSGENYWD AAQTCQRLNG SLATFSTDQE LRFVLAQEWD QPERSFGWKD QRKLWVGYQY VITGRNRSLE GRWEVAFKGS SEVFLPPDPI FASAMSENDN VFCAQLQCFH FPTLRHHDLH SWHAESCYEK SSFLCKRSQT CVDIKDNVVD EGFYFTPKGD DPCLSCTCHG GEPEMCVAAL CERPQGCQQY RKDPKECCKF MCLDPDGNSL FDSMASGMRL VVSCISSFLI LSLLLFMVHR LRQRRRERIE SLIGANLHHF NLGRRIPGFD YGPDGFGTGL TPLHLSDDGE GGTFHFHDPP PPYTAYKYPD IGQPDDPPPP YEASIHPDSV FYDPADDDAF EPVEVSLPAP GDGGSEGALL RRLEQPLPTA GASLADLEDS ADSSSALLVP PDPAQSGSTP AAEALPGGGR HSRSSLNTVV
Research Areas
Citations (0)

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Background

DGCR2 encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome.

References

Georgi, A., et al. Psychiatr. Genet. 19 (2), 104 (2009)
Wang, P., et al. BMC Genomics 10, 518 (2009)
Ishiguro, H., et al. Psychiatr. Genet. 18(5):255-256(2008)
Pellikka, M., et al. J. Thromb. Thrombolysis 26(2):91-96(2008)
Olsen, J.V., et al. Cell 127(3):635-648(2006)

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$ 162.50
$ 54.50
Cat# AP9451c
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