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Slco1a1 Rabbit pAb
Slco1a1 Rabbit pAb
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Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P46720 |
| Reactivity | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 74 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from rat Slco1a1 |
| Epitope Specificity | 2-90/670 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Basolateral cell membrane |
| SIMILARITY | Belongs to the organo anion transporter (TC 2.A.60) family. [SIMILARITY] Contains 1 Kazal-like domain. |
| SUBUNIT | Binds to PDZK1. Interaction with PDZK1 is required for expression on hepatocyte surface. |
| Post-translational modifications | Glycosylated. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | mediates the transport of sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes |
| Gene ID | 50572 |
|---|---|
| Other Names | Solute carrier organic anion transporter family member 1A1, Organic anion-transporting polypeptide 1, OATP-1, Sodium-independent organic anion transporter 1, Solute carrier family 21 member 1, Slco1a1 {ECO:0000312|RGD:3700} |
| Target/Specificity | Highly expressed in liver and kidney, and at lower levels in brain, lung, skeletal muscle and proximal colon. |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | Slco1a1 {ECO:0000312|RGD:3700} |
|---|---|
| Function | Mediates the Na(+)-independent transport of organic anions such as steroid sulfate conjugates (dehydroepiandrosterone sulfate (DHEAS), 17-beta-glucuronosyl estradiol, estrone-3-sulfate), conjugated (taurocholate) and unconjugated (cholate) bile acids, prostaglandin E2 (PGE2) and L-thyroxine T4 (PubMed:19129463). Also capable of transporting sulfobromophthalein (BSP), ouabain and gadoxetate (By similarity). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). |
| Cellular Location | Basolateral cell membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed in liver and kidney, and at lower levels in brain, lung, skeletal muscle and proximal colon |
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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If you have any additional inquiries please email technical services at tech@abcepta.com.
$ 385.00
Cat# AP94652
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