|Application ||WB, E|
|Calculated MW||27751 Da|
|Antigen Region||91-119 aa|
|Other Names||Inhibitor of growth protein 5, p28ING5, ING5|
|Target/Specificity||This ING5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-119 amino acids from the Central region of human ING5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ING5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653). Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715).|
|Cellular Location||Nucleus. Chromosome. Note=Localizes to transcription start sites.|
|Tissue Location||Down-regulated in bone marrow cells in acute myeloid leukemia patients as compared with normal bone marrow cells|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
ING5 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. [provided by RefSeq].
Ullah, M., et al. Mol. Cell. Biol. 28(22):6828-6843(2008)
Champagne, K.S., et al. Proteins 72(4):1371-1376(2008)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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