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GPR133 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q6QNK2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 96530 Da |
| Antigen Region | 471-498 aa |
| Gene ID | 283383 |
|---|---|
| Other Names | Probable G-protein coupled receptor 133, G-protein coupled receptor PGR25, GPR133, PGR25 |
| Target/Specificity | This GPR133 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 471-498 amino acids from the Central region of human GPR133. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GPR133 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADGRD1 {ECO:0000303|PubMed:25713288, ECO:0000312|HGNC:HGNC:19893} |
|---|---|
| Function | Adhesion G-protein coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta- hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens (PubMed:39884271). Also activated by methenolone drug (PubMed:39884271). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:39884271). ADGRD1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:22025619, PubMed:22575658, PubMed:35447113, PubMed:39884271). Acts as a 5alpha- DHT receptor in muscle cells, thereby increasing intracellular cyclic AMP (cAMP) levels and enhancing muscle strength (PubMed:39884271). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Up-regulated in CD133(+) cell population of glioblastoma. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
GPR133 is an orphan receptor.
References
Tonjes, A., et al. Hum. Mol. Genet. 18(23):4662-4668(2009)
Marroni, F., et al. Circ Cardiovasc Genet 2(4):322-328(2009)
Otowa, T., et al. J. Hum. Genet. 54(2):122-126(2009)
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$ 385.00
$ 150.00
Cat# AP9499C
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