|Application ||WB, E|
|Calculated MW||18048 Da|
|Antigen Region||121-150 aa|
|Other Names||Neuropeptide W, Preproprotein L8, hPPL8, Neuropeptide W-23, NPW23, hL8, Neuropeptide W-30, NPW30, hL8C, NPW, PPL8, PPNPW|
|Target/Specificity||This NPW antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 121-150 amino acids from the C-terminal region of human NPW.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NPW Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30.|
|Tissue Location||Detected at high levels in the substantia nigra, fetal kidney and trachea; at lower levels in testis, uterus, ovary and placenta. Not detectable in many regions of the central nervous system Also detected at high levels in lymphoblastic leukemia and colorectal adenocarcinoma|
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Provided below are standard protocols that you may find useful for product applications.
NPW is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. [provided by RefSeq].
Luttrell, L.M. Mol. Biotechnol. 39(3):239-264(2008)
Singh, G., et al. Br. J. Pharmacol. 148(8):1033-1041(2006)
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