|Application ||WB, E|
|Calculated MW||33698 Da|
|Antigen Region||254-283 aa|
|Other Names||Ethylmalonyl-CoA decarboxylase, Enoyl-CoA hydratase domain-containing protein 1, Methylmalonyl-CoA decarboxylase, MMCD, ECHDC1|
|Target/Specificity||This ECHDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 254-283 amino acids from the C-terminal region of human ECHDC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ECHDC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading (PubMed:22016388). Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity).|
|Cellular Location||Cytoplasm, cytosol.|
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Provided below are standard protocols that you may find useful for product applications.
ECHDC1 belongs to the enoyl-CoA hydratase/isomerase family. There are two named isoforms.
Zheng, W., et al. Cancer Epidemiol. Biomarkers Prev. 18(10):2761-2764(2009)
Menachem, T.D., et al. Fam. Cancer 8(4):399-402(2009)
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