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FLVC2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UPI3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 57241 Da |
| Antigen Region | 478-507 aa |
| Gene ID | 55640 |
|---|---|
| Other Names | Feline leukemia virus subgroup C receptor-related protein 2, Calcium-chelate transporter, CCT, FLVCR2, C14orf58 |
| Target/Specificity | This FLVC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 478-507 amino acids from the C-terminal region of human FLVC2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FLVC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FLVCR2 |
|---|---|
| Synonyms | C14orf58 |
| Function | Putative heme b importer/sensor involved in heme homeostasis in response to the metabolic state of the cell and to diet. May act as a sensor of cytosolic and/or mitochondrial heme levels to regulate mitochondrial respiration processes, ATP synthesis and thermogenesis. At low heme levels, interacts with components of electron transfer chain (ETC) complexes and ATP2A2, leading to ubiquitin-mediated degradation of ATP2A2 and inhibition of thermogenesis. Upon heme binding, dissociates from ETC complexes to allow switching from mitochondrial ATP synthesis to thermogenesis. Alternatively, in coordination with ATP2A2 may mediate calcium transport and signaling in response to heme. |
| Cellular Location | Mitochondrion membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Primarily resides in mitochondria where it interacts with components of the electron transfer chain complexes III, IV and V. Colocalizes with ATP2A2 at the mitochondrial- ER contact junction. |
| Tissue Location | Expressed in non-hematopoietic tissues, with relative abundant expression in brain, placenta, lung, liver and kidney (PubMed:20823265). Also expressed in hematopoietic tissues (fetal liver, spleen, lymph node, thymus, leukocytes and bone marrow) (PubMed:20823265). Found in acidophil cells of the pituitary that secrete growth hormone and prolactin (at protein level) (PubMed:14729055). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The FLVCR2 gene encodes a transmembrane protein that belongs to the major facilitator superfamily of secondary carriers that transport small solutes in response to chemiosmotic ion gradients, such as calcium.
References
Meyer, E., et al. Am. J. Hum. Genet. 86(3):471-478(2010)
Brown, J.K., et al. J. Virol. 80(4):1742-1751(2006)
Brasier, G., et al. Exp. Cell Res. 293(1):31-42(2004)
Heilig, R., et al. Nature 421(6923):601-607(2003)
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