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HES7 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BYE0 |
| Other Accession | Q8BKT2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 24899 Da |
| Antigen Region | 26-55 aa |
| Gene ID | 84667 |
|---|---|
| Other Names | Transcription factor HES-7, hHes7, Class B basic helix-loop-helix protein 37, bHLHb37, Hairy and enhancer of split 7, bHLH factor Hes7, HES7, BHLHB37 |
| Target/Specificity | This HES7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human HES7. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HES7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HES7 |
|---|---|
| Synonyms | BHLHB37 |
| Function | Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation (By similarity). |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
HES7 is a member of the hairy and enhancer of split family of bHLH transcription factors. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton.
References
Sparrow, D.B., et al. Hum. Mol. Genet. 17(23):3761-3766(2008)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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