|Application ||IHC-P, WB, E|
|Other Accession||Q6AXZ3, Q9JK24, Q5E9G1|
|Calculated MW||53316 Da|
|Antigen Region||50-79 aa|
|Other Names||Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma, Protein phosphatase subunit G5PR, Rhabdomyosarcoma antigen MU-RMS-406A/6C, PPP2R3C, C14orf10, G5PR|
|Target/Specificity||This P2R3C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-79 amino acids from the N-terminal region of human P2R3C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||P2R3C Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May regulate MCM3AP phosphorylation through phosphatase recruitment (By similarity). May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex (PubMed:24333728). May play a role in the activation-induced cell death of B-cells (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Note=Excluded from the nucleoli Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis.|
|Tissue Location||Ubiquitously expressed in brain and other tissues.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
P2R3C may regulate MCM3AP phosphorylation through phosphatase recruitment. It may play a role in the activation-induced cell death of B-cells (By similarity).
Xing, Y., et al. J. Exp. Med. 202(5):707-719(2005)
Kamnasaran, D., et al. Genomics 85(5):608-621(2005)
Kono, Y., et al. Genes Cells 7(8):821-834(2002)
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