P2R3C Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
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Primary Accession | Q969Q6 |
Other Accession | Q6AXZ3, Q9JK24, Q5E9G1 |
Reactivity | Human |
Predicted | Bovine, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 53316 Da |
Antigen Region | 50-79 aa |
Gene ID | 55012 |
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Other Names | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma, Protein phosphatase subunit G5PR, Rhabdomyosarcoma antigen MU-RMS-406A/6C, PPP2R3C, C14orf10, G5PR |
Target/Specificity | This P2R3C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-79 amino acids from the N-terminal region of human P2R3C. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | P2R3C Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PPP2R3C |
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Synonyms | C14orf10, G5PR |
Function | May regulate MCM3AP phosphorylation through phosphatase recruitment (By similarity). May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex (PubMed:24333728). May play a role in the activation-induced cell death of B-cells (By similarity). |
Cellular Location | Nucleus. Cytoplasm. Note=Excluded from the nucleoli Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis. |
Tissue Location | Ubiquitously expressed in brain and other tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
P2R3C may regulate MCM3AP phosphorylation through phosphatase recruitment. It may play a role in the activation-induced cell death of B-cells (By similarity).
References
Xing, Y., et al. J. Exp. Med. 202(5):707-719(2005)
Kamnasaran, D., et al. Genomics 85(5):608-621(2005)
Kono, Y., et al. Genes Cells 7(8):821-834(2002)
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