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PKHH2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q8IVE3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 168229 Da |
| Antigen Region | 1049-1079 aa |
| Gene ID | 130271 |
|---|---|
| Other Names | Pleckstrin homology domain-containing family H member 2, PLEKHH2, KIAA2028 |
| Target/Specificity | This PKHH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1049-1079 amino acids from the C-terminal region of human PKHH2. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PKHH2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLEKHH2 |
|---|---|
| Synonyms | KIAA2028 |
| Function | In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia. |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Note=Localizes to foot process of podocytes. Localization to peripheral regions of lamellipodia seems to be dependent on PI3K |
| Tissue Location | Kidney. Reduced expression in patients with focal segmental glomerulosclerosis. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Greene, C.N., et al. Hum. Genet. 124(3):255-262(2008)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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$ 365.00
$ 140.00
Cat# AP9773b
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