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>   home   >   Products   >   Primary Antibodies   >   CLDN23 Antibody (C-term)   

CLDN23 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CLDN23 Antibody (C-term) AP9832B
    Western blot analysis of CLDN23 Antibody (C-term) (Cat. #AP9832b) in mouse bladder tissue lysates (35ug/lane). CLDN23 (arrow) was detected using the purified Pab.
  • IHC-P - CLDN23 Antibody (C-term) AP9832B
    CLDN23 Antibody (C-term) (Cat. #AP9832b) IHC analysis in formalin fixed and paraffin embedded colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CLDN23 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q96B33
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 31915 Da
Antigen Region 228-257 aa
Additional Information
Gene ID 137075
Other Names Claudin-23, CLDN23
Target/Specificity This CLDN23 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-257 amino acids from the C-terminal region of human CLDN23.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCLDN23 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLDN23
Function Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Cellular Location Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in germinal center B-cells, placenta, stomach as well as in colon tumor.
Citations (0)

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Background

CLDN23 is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C. It is a candidate tumor suppressor gene implicated in intestinal-type gastric cancer.

References

Rikova, K., et al. Cell 131(6):1190-1203(2007)
Ballana, E., et al. BMC Med. Genet. 8, 81 (2007) :
Katoh, M., et al. Int. J. Mol. Med. 11(6):683-689(2003)
Venter, J.C., et al. Science 291(5507):1304-1351(2001)

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Cat# AP9832B
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