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FASTKD2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9NYY8 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 81463 Da |
| Antigen Region | 318-347 aa |
| Gene ID | 22868 |
|---|---|
| Other Names | FAST kinase domain-containing protein 2, FASTKD2, KIAA0971 |
| Target/Specificity | This FASTKD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 318~347 amino acids from the Central region of human FASTKD2. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FASTKD2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FASTKD2 {ECO:0000303|PubMed:27667664, ECO:0000312|HGNC:HGNC:29160} |
|---|---|
| Function | Plays an important role in assembly of the mitochondrial large ribosomal subunit (PubMed:25683715). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt- rRNA), controls 16S mt-rRNA abundance and is required for intra- mitochondrial translation (PubMed:27667664, PubMed:25683715, PubMed:26370583). May play a role in mitochondrial apoptosis. |
| Cellular Location | Mitochondrion matrix, mitochondrion nucleoid Mitochondrion matrix. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. |
| Tissue Location | Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in heart, smooth muscle and thyroid. |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that is localized in the mitochondrial inner compartment and that may play a role in mitochondrial apoptosis. Nonsense mutations have been reported to result in cytochrome c oxidase deficiency.
References
Ghezzi, D., et al. Am. J. Hum. Genet. 83(3):415-423(2008)
Hu, R.M., et al. Proc. Natl. Acad. Sci. U.S.A. 97(17):9543-9548(2000)
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$ 365.00
$ 140.00
Cat# AP9877c
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