Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
HCCS Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P53701 |
| Other Accession | Q5F339, A5PJG7 |
| Reactivity | Human |
| Predicted | Bovine, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 30602 Da |
| Antigen Region | 173-200 aa |
| Gene ID | 3052 |
|---|---|
| Other Names | Cytochrome c-type heme lyase, CCHL, Holocytochrome c-type synthase, HCCS, CCHL |
| Target/Specificity | This HCCS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-200 amino acids from the Central region of human HCCS. |
| Dilution | WB~~1:4000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HCCS Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HCCS (HGNC:4837) |
|---|---|
| Synonyms | CCHL |
| Function | Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome. |
| Cellular Location | Mitochondrion inner membrane. Membrane; Lipid-anchor |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene.
References
Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)
Wimplinger, I., et al. Mol. Vis. 13, 1475-1482 (2007)
Wimplinger, I., et al. Am. J. Hum. Genet. 79(5):878-889(2006)
Nakashima-Kamimura, N., et al. J. Cell. Sci. 118 (PT 22), 5357-5367 (2005)
Prakash, S.K., et al. Hum. Mol. Genet. 11(25):3237-3248(2002)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
