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POLL Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UGP5 |
| Other Accession | Q5RKI3, Q9QXE2, Q4R380 |
| Reactivity | Human |
| Predicted | Monkey, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 63482 Da |
| Antigen Region | 549-575 aa |
| Gene ID | 27343 |
|---|---|
| Other Names | DNA polymerase lambda, Pol Lambda, 4299-, DNA polymerase beta-2, Pol beta2, DNA polymerase kappa, POLL |
| Target/Specificity | This POLL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 549-575 amino acids from the C-terminal region of human POLL. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | POLL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | POLL (HGNC:9184) |
|---|---|
| Function | DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240, PubMed:30250067). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double- strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240, PubMed:30250067). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10887191, PubMed:10982892, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Also has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195). |
| Cellular Location | Nucleus. Chromosome. Note=Accumulates at sites of DNA damage |
| Tissue Location | Expressed in a number of tissues. Abundant in testis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes.
References
Brown, J.A., et al. J. Mol. Biol. 395(2):282-290(2010)
van Loon, B., et al. Proc. Natl. Acad. Sci. U.S.A. 106(43):18201-18206(2009)
Garcia-Diaz, M., et al. Nat. Struct. Mol. Biol. 16(9):967-972(2009)
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