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CA 19-9
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC |
|---|---|
| Primary Accession | Q969X2 |
| Host | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 38068 Da |
| Gene ID | 30815 |
|---|---|
| Gene Name | ST6GALNAC6 |
| Other Names | Alpha-N-acetylgalactosaminide alpha-2, 6-sialyltransferase 6, 2.4.99.-, GalNAc alpha-2, 6-sialyltransferase VI, ST6GalNAc VI, ST6GalNAcVI, hST6GalNAc VI, Sialyltransferase 7F, SIAT7-F, ST6GALNAC6, SIAT7F |
| Dilution | IHC~~1:100~500 |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CA 19-9 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ST6GALNAC6 |
|---|---|
| Synonyms | SIAT7F |
| Function | Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3- linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:12668675, PubMed:17123352). Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (PubMed:12668675). Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) (By similarity). |
| Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
| Tissue Location | Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines. |
Research Areas
Citations (0)
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Application Protocols
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$ 780.00
Cat# APA280
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