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> home > Products > Primary Antibodies > Antibody Collections > Recombinant Antibodies > Anti-B7-H2 / ICOSL / CD275 Reference Antibody (prezalumab)
Anti-B7-H2 / ICOSL / CD275 Reference Antibody (prezalumab)
Recombinant Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, E, FTA |
|---|---|
| Primary Accession | O75144 |
| Reactivity | Cynomolgus, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2SA |
| Calculated MW | 145 KDa |
| Target/Specificity | B7-H2 / ICOSL / CD275 |
|---|---|
| Endotoxin | < 0.001EU/ µg,determined by LAL method. |
| Conjugation | Unconjugated |
| Expression system | CHO Cell |
| Format | Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column. |
| Storage | -80°C for 2 years under sterile conditions； -20°C for 1 year under sterile conditions；Avoid repeated freeze-thaw cycles. |
| Name | ICOSLG |
|---|---|
| Synonyms | B7H2, B7RP1, ICOSL, KIAA0653 |
| Function | Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 365.00
Cat# APR10011
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