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Anti-CDH17 / Cadherin-17 Reference Antibody (10C12)

Recombinant Antibody

     
  •  - Anti-CDH17 / Cadherin-17 Reference Antibody (10C12) APR10181
    Anti-CDH17 / Cadherin-17 Reference Antibody (10C12) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%
    detail
  •  - Anti-CDH17 / Cadherin-17 Reference Antibody (10C12) APR10181
    The purity of Anti-CDH17 / Cadherin-17 Reference Antibody (10C12)is more than 98.15% ,determined by SEC-HPLC.
    detail
  •  - Anti-CDH17 / Cadherin-17 Reference Antibody (10C12) APR10181
    Immobilized human CDH17, His Tag at 2  µg/mL can bind Anti-CDH17 / Cadherin-17 Reference Antibody (10C12),EC50=0.00468 µg/mL
    detail
  •  - Anti-CDH17 / Cadherin-17 Reference Antibody (10C12) APR10181
    Human CDH17 HEK293 cells were stained with Anti-CDH17 / Cadherin-17 Reference Antibody (10C12) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC240=0.06889 µg/mL
    detail
  •  - Anti-CDH17 / Cadherin-17 Reference Antibody (10C12) APR10181
    The endocytosis ratio 10C12 by Human CDH17 HEK293 increased with the increase of antibody concentration, and the Internalization Rate (%) reached 80% at antibody concentration of 2 nM.
    detail
  •  - Anti-CDH17 / Cadherin-17 Reference Antibody (10C12) APR10181
    10C12 inhibited the tumor growth of COLO205 on nude mice. The result showed significant anti-tumor effects, with an tumor inhibition rate (TGI) of 70.0% at 5 mpk at D26.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, E, FTA
Primary Accession Q12864
Reactivity Human
Clonality Monoclonal
Isotype IgG1
Calculated MW 143.68 KDa
Additional Information
Target/Specificity CDH17 / Cadherin-17
Endotoxin < 0.001EU/ µg,determined by LAL method.
Conjugation Unconjugated
Expression system CHO Cell
Format Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.
Storage -80°C for 2 years under sterile conditions; -20°C for 1 year under sterile conditions;Avoid repeated freeze-thaw cycles.
Protein Information
Name CDH17
Function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin.
Research Areas
Citations (0)
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$ 365.00
Cat# APR10181
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