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> home > Products > Primary Antibodies > Antibody Collections > Recombinant Antibodies > Anti-TNFSF12 / TWEAK Reference Antibody (RO5458640)
Anti-TNFSF12 / TWEAK Reference Antibody (RO5458640)
Recombinant Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, Kinetics, Animal Model |
|---|---|
| Primary Accession | O43508 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 146.02 KDa |
| Target/Specificity | TNFSF12 / TWEAK |
|---|---|
| Endotoxin | < 0.001EU/ µg,determined by LAL method. |
| Conjugation | Unconjugated |
| Expression system | CHO Cell |
| Format | Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column. |
| Name | TNFSF12 |
|---|---|
| Synonyms | APO3L, DR3LG |
| Function | Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. |
| Cellular Location | Cell membrane; Single-pass type II membrane protein [Isoform TWE-PRIL]: Cell membrane; Single-pass membrane protein |
| Tissue Location | Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain |
Research Areas
Citations (0)
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Application Protocols
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$ 385.00
Cat# APR10347
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