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CLPH Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q96KC9 |
| Other Accession | NP_149113, 90652863 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 43003 Da |
| Application Notes | CLPH antibody can be used for detection of CLPH by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. |
| Gene ID | 85438 |
|---|---|
| Target/Specificity | C4orf35; |
| Reconstitution & Storage | CLPH antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | CLPH Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CABS1 |
|---|---|
| Synonyms | C4orf35 |
| Function | Calcium-binding protein (By similarity). Essential for maintaining the structural integrity of the sperm flagella (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q68FX6}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q68FX6}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q8C633} Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q8C633}. Note=Mostly cytoplasmic, but associated with the mitochondrial inner membrane during the last steps of spermatid differentiation. Localizes to the principal piece of the sperm flagellum (By similarity). {ECO:0000250|UniProtKB:Q68FX6, ECO:0000250|UniProtKB:Q8C633} |
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Provided below are standard protocols that you may find useful for product applications.
Background
CLPH Antibody: CLPH (Casein-Like phosphoprotein) is a recently discovered, evolutionarily conserved, testis-specific cytoplasmic protein expressed exclusively in postmeiotic germ cells in rat spermatogenesis. CLPH is a novel casein kinase 2-phosphorylated disordered and calcium-binding protein that displays strong variation in relative expression levels during spermatogenesis. It is frequently associated with the mitochondrial inner membrane during the last steps of spermatid differentiation and is involved in the extremely complex structural rearrangements occurring in haploid germ cells during spermiogenesis.
References
Calvel P, Kervarrec C, Lavigne R, et al. CLPH, a novel casein kinase 2-phosphorylated disordered protein, is specifically associated with postmeiotic germ cells in rat spermatogenesis. J. Proteome Res.2009; 8:2953-65.
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