ECRG1 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q6ZMR5 |
Other Accession | Q6ZMR5, 167466250 |
Reactivity | Human, Mouse, Rat |
Host | Chicken |
Clonality | Polyclonal |
Isotype | IgY |
Calculated MW | 47226 Da |
Application Notes | ECRG1 antibody can be used for detection of ECRG1 by Western blot at 1 µg/mL. |
Gene ID | 339967 |
---|---|
Target/Specificity | TMPRSS11A; At least two isoforms of ECRG1 are known to exist; ECRG1 antibody is predicted to not cross-react with other ECRG family members. |
Reconstitution & Storage | ECRG1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Precautions | ECRG1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TMPRSS11A |
---|---|
Synonyms | ECRG1, HATL1, HESP |
Function | Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest. |
Cellular Location | Membrane; Single-pass type II membrane protein |
Tissue Location | Expressed in esophagus, liver, colon and lung. Down-regulated in esophagus cancers. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
ECRG1 Antibody: Epidermal type-II transmembrane serine protease (ECRG1), also known as TMPRSS11A, is a member of a novel esophageal cancer-related gene family. It is a type-II transmembrane serine protease which may play a role in cellular senescence. It is expressed in esophagus, liver, colon and lung. Overexpression of ECRG1 inhibits cell growth and induces G1 cell cycle arrest. It is down-regulated in esophagus cancers (EC) and might play important roles in the initiation and progression of EC.
References
Yueying W, Jianbo W, Hailin L, et al. ECRG1, a novel esophageal gene, cloned and identified from human esophagus and its inhibition effect on tumors. Carcinogenesis 2008; 29:157-60.
Zhao N, Wang J, Cui Y, et al. Induction of G1 cell cycle arrest and P15INK4b expression by ECRG1 through interaction with Miz-1. J. Cell Biochem. 2004; 92:65-76
Zhao N, Huang G, Guo L, et al. ECRG1, a novel candidate of tumor suppressor gene in the esophageal carcinoma, triggers a senescent program in NIH3T3 cells. Exp. Biol. Med. 2006; 231:84-90.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.