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ARR3 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P36575 |
| Other Accession | NP_004303, 156071467 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | Predicted: 43 kDa Observed: 47 kDa |
| Application Notes | ARR3 antibody can be used for detection of ARR3 by Western blot at 0.5 - 1 µg/ml. |
| Gene ID | 407 |
|---|---|
| Target/Specificity | ARR3; ARR3 antibody is human, mouse and rat reactive. At least three isoforms of ARR3 are known to exist. This antibody is predicted to not cross-react with other members of the arrestin protein family. |
| Reconstitution & Storage | ARR3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | ARR3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARR3 |
|---|---|
| Synonyms | ARRX, CAR |
| Function | May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins. |
| Cellular Location | Photoreceptor inner segment {ECO:0000250|UniProtKB:Q9EQP6}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q9EQP6} |
| Tissue Location | Inner and outer segments, and the inner plexiform regions of the retina |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Arrestin 3 (ARR3) belongs to the Arrestin family of proteins that function as negative regulators of G protein-coupled receptor (GPCR) signaling (1,2). ARR3 binds the c-Jun N-terminal kinase 3 (JNK3) and scaffolds the apoptosis signal-regulating kinase 1 (ASK1)-MAPK kinase4-JNK3 cascade in a receptor-independent fashion, promoting JNK3 phosphorylation (3,4). ARR3 also mediates the internalization of the C-C chemokine receptor CCR7 upon the binding of its ligand CCL19, but not CCL21, suggesting that it helps mediate CCR7 receptor desensitization (5).
References
Murakami A, Yajima T, Sakuma H, et al. X-arrestin: a new retinal arrestin mapping to the X chromosome. FEBS Lett. 1993; 334:203-9.
Gurevich VV and Gurevich EV. The structural basis of arrestin-mediated regulation of G-protein-coupled receptors. Pharmacol. Ther. 2006; 110:465-502.
Song X, Coffa S, Fu H, et al. How does arrestin assemble MAPKs into a signaling complex? J. Biol. Chem. 2009; 284:685-95.
Seo J, Tsakem EL, Breitman M, et al. Identification of arrestin-3-specific residues necessary for JNK3 kinase activation. J. Biol. Chem. 2011; 286:27894-901.
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