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C22orf18 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant C22orf18.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, IP, E |
|---|---|
| Primary Accession | Q9NSP4 |
| Other Accession | BC000705 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 4C12-2C8 |
| Calculated MW | 19737 Da |
| Gene ID | 79019 |
|---|---|
| Other Names | Centromere protein M, CENP-M, Interphase centromere complex protein 39, Proliferation-associated nuclear element protein 1, CENPM, C22orf18, ICEN39, PANE1 |
| Target/Specificity | C22orf18 (AAH00705, 1 a.a. ~ 180 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | C22orf18 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPM is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).
References
Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. Hosgood HD 3rd, et al. Occup Environ Med, 2009 Dec. PMID 19773279.Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. Izuta H, et al. Genes Cells, 2006 Jun. PMID 16716197.The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. Okada M, et al. Nat Cell Biol, 2006 May. PMID 16622420.The human CENP-A centromeric nucleosome-associated complex. Foltz DR, et al. Nat Cell Biol, 2006 May. PMID 16622419.The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL. Brickner AG, et al. Blood, 2006 May 1. PMID 16391015.
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