FBLIM1 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant FBLIM1.
|Calculated MW||40670 Da|
|Other Names||Filamin-binding LIM protein 1, FBLP-1, Migfilin, Mitogen-inducible 2-interacting protein, MIG2-interacting protein, FBLIM1, FBLP1|
|Target/Specificity||FBLIM1 (NP_060026, 270 a.a. ~ 373 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||FBLIM1 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms.
Migfilin interacts with Src and contributes to cell-matrix adhesion-mediated survival signaling. Zhao J, et al. J Biol Chem, 2009 Dec 4. PMID 19833732.Migfilin, a molecular switch in regulation of integrin activation. Ithychanda SS, et al. J Biol Chem, 2009 Feb 13. PMID 19074766.Structural basis of the migfilin-filamin interaction and competition with integrin beta tails. Lad Y, et al. J Biol Chem, 2008 Dec 12. PMID 18829455.Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome. Lai-Cheong JE, et al. J Invest Dermatol, 2008 Sep. PMID 18528435.Increased cytoplasmic level of migfilin is associated with higher grades of human leiomyosarcoma. Papachristou DJ, et al. Histopathology, 2007 Oct. PMID 17711449.
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