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FCGR2B Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant FCGR2B.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P31994 |
| Other Accession | BC031992 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 2E11 |
| Calculated MW | 34044 Da |
| Gene ID | 2213 |
|---|---|
| Other Names | Low affinity immunoglobulin gamma Fc region receptor II-b, IgG Fc receptor II-b, CDw32, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b, CD32, FCGR2B, CD32, FCG2, IGFR2 |
| Target/Specificity | FCGR2B (AAH31992, 45 a.a. ~ 154 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | FCGR2B Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
References
Dengue hemorrhagic fever is associated with polymorphisms in JAK1. Silva LK, et al. Eur J Hum Genet, 2010 Jun 30. PMID 20588308.The role of Fc gamma receptors polymorphisms in bullous pemphigoid. Guilabert A, et al. J Am Acad Dermatol, 2010 Jul. PMID 20542180.Copy number, linkage disequilibrium and disease association in the FCGR locus. Niederer HA, et al. Hum Mol Genet, 2010 Aug 15. PMID 20508037.An FcgammaRIIb transmembrane polymorphism in Chinese ITP patients. Xu J, et al. Platelets, 2010. PMID 20507212.SNPs of Fc-gamma receptor genes and chronic periodontitis. Chai L, et al. J Dent Res, 2010 Jul. PMID 20439936.
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