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GJB3 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant GJB3.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | O75712 |
| Other Accession | BC012918 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 3B4-1B3 |
| Calculated MW | 30818 Da |
| Gene ID | 2707 |
|---|---|
| Other Names | Gap junction beta-3 protein, Connexin-31, Cx31, GJB3, CX31 |
| Target/Specificity | GJB3 (AAH12918.1, 1 a.a. ~ 270 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | GJB3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene can cause non-syndromic deafness or erythrokeratodermia variabilis, a skin disorder. Alternative splicing results in multiple transcript variants encoding the same protein.
References
1.EKV mutant connexin 31 associated cell death is mediated by ER stress.Tattersall D, Scott CA, Gray C, Zicha D, Kelsell DP.Hum Mol Genet. 2009 Dec 15;18(24):4734-45. Epub 2009 Sep 14.
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