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Connexin 31 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | O75712 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 30818 Da |
| Antigen Region | 227-257 aa |
| Gene ID | 2707 |
|---|---|
| Other Names | Gap junction beta-3 protein, Connexin-31, Cx31, GJB3, CX31 |
| Target/Specificity | This Connexin 31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-257 amino acids from the C-terminal region of human Connexin 31. |
| Dilution | IHC-P~~1:50~100 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Connexin 31 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GJB3 |
|---|---|
| Synonyms | CX31 |
| Function | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, gap junction |
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Provided below are standard protocols that you may find useful for product applications.
Background
Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variabilis (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.
References
Mhatre, A.N., et al., Clin. Genet. 63(2):154-159 (2003).
Diestel, S., et al., Biochem. Biophys. Res. Commun. 296(3):721-728 (2002).
Di, W.L., et al., Hum. Mol. Genet. 11(17):2005-2014 (2002).
Gottfried, I., et al., Hum. Mol. Genet. 11(11):1311-1316 (2002).
Wenzel, K., et al., Biochem. Biophys. Res. Commun. 248(3):910-915 (1998).
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