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GSDMDC1 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a full length recombinant GSDMDC1.

     
  • IF - GSDMDC1 Antibody (monoclonal) (M01) AT2269a
    Immunofluorescence of monoclonal antibody to GSDMDC1 on HeLa cell. [antibody concentration 10 ug/ml]
    detail
  • WB - GSDMDC1 Antibody (monoclonal) (M01) AT2269a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (78.98 KDa) .
    detail
  • WB - GSDMDC1 Antibody (monoclonal) (M01) AT2269a
    GSDMDC1 monoclonal antibody (M01), clone 3F12-1B2 Western Blot analysis of GSDMDC1 expression in Jurkat ( (Cat # AT2269a )
    detail
  • WB - GSDMDC1 Antibody (monoclonal) (M01) AT2269a
    Western Blot analysis of GSDMD expression in transfected 293T cell line by GSDMDC1 monoclonal antibody (M01), clone 3F12-1B2.

    Lane 1: GSDMD transfected lysate (Predicted MW: 52.8 KDa).
    Lane 2: Non-transfected lysate.
    detail
  • IHC - GSDMDC1 Antibody (monoclonal) (M01) AT2269a
    Immunoperoxidase of monoclonal antibody to GSDMDC1 on formalin-fixed paraffin-embedded human tonsil tissue. [antibody concentration 3 ug/ml]
    detail
  • E - GSDMDC1 Antibody (monoclonal) (M01) AT2269a
    Detection limit for recombinant GST tagged GSDMDC1 is approximately 0.3ng/ml as a capture antibody.
    detail
  • SPECIFICATION
  • CITATIONS: 1
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, IF, E
Primary Accession P57764
Other Accession BC008904
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 kappa
Clone Names 3F12-1B2
Calculated MW 52801 Da
Additional Information
Gene ID 79792
Other Names Gasdermin-D, Gasdermin domain-containing protein 1, GSDMD, DFNA5L, GSDMDC1
Target/Specificity GSDMDC1 (AAH08904, 1 a.a. ~ 484 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsGSDMDC1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations ( 0 )

Background

Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described.

References

Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium. Saeki N, et al. Genes Chromosomes Cancer, 2009 Mar. PMID 19051310.Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Tamura M, et al. Genomics, 2007 May. PMID 17350798.DNA sequence and analysis of human chromosome 8. Nusbaum C, et al. Nature, 2006 Jan 19. PMID 16421571.Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Rush J, et al. Nat Biotechnol, 2005 Jan. PMID 15592455.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.

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$ 350.00
Cat# AT2269a
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Availability: 7-10 days
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