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HDAC11 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant HDAC11.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q96DB2 |
| Other Accession | BC009676 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 1C2-2G5 |
| Calculated MW | 39183 Da |
| Gene ID | 79885 |
|---|---|
| Other Names | Histone deacetylase 11, HD11, HDAC11 |
| Target/Specificity | HDAC11 (AAH09676, 1 a.a. ~ 347 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | HDAC11 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.
References
Differential histone deacetylase mRNA expression patterns in amyotrophic lateral sclerosis. Janssen C, et al. J Neuropathol Exp Neurol, 2010 Jun. PMID 20467334. Acetylation/deacetylation modulates the stability of DNA replication licensing factor Cdt1. Glozak MA, et al. J Biol Chem, 2009 Apr 24. PMID 19276081. From immunity to tolerance through HDAC. Georgopoulos K. Nat Immunol, 2009 Jan. PMID 19088734. The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance. Villagra A, et al. Nat Immunol, 2009 Jan. PMID 19011628. MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo. Fournel M, et al. Mol Cancer Ther, 2008 Apr. PMID 18413790.
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