|Application ||IF, E|
|Calculated MW||49964 Da|
|Other Names||Homogentisate 1, 2-dioxygenase, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase, HGD, HGO|
|Target/Specificity||HGD (NP_000178, 377 a.a. ~ 445 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||HGD Antibody (monoclonal) (M10) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the enzyme homogentisate 1,2 dioxygenase. This enzyme is involved in the catabolism of the amino acids tyrosine and phenylalanine. Mutations in this gene are the cause of the autosomal recessive metabolism disorder alkaptonuria.
Alkaptonuria Introne WJ, et al. , 1993. PMID 20301627.Human variation in alcohol response is influenced by variation in neuronal signaling genes. Joslyn G, et al. Alcohol Clin Exp Res, 2010 May. PMID 20201926.Mutation spectrum of homogentisic acid oxidase (HGD) in alkaptonuria. Vilboux T, et al. Hum Mutat, 2009 Dec. PMID 19862842.R58fs mutation in the HGD gene in a family with alkaptonuria in the UAE. Abdulrazzaq YM, et al. Ann Hum Genet, 2009 Jan. PMID 18945288.Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.
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