KLF12 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant KLF12.
|Calculated MW||44240 Da|
|Other Names||Krueppel-like factor 12, Transcriptional repressor AP-2rep, KLF12, AP2REP|
|Target/Specificity||KLF12 (NP_009180, 1 a.a. ~ 90 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||KLF12 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Petersen GM, et al. Nat Genet, 2010 Mar. PMID 20101243.A functionally relevant IRF5 haplotype is associated with reduced risk to Wegener's granulomatosis. Wieczorek S, et al. J Mol Med, 2010 Apr. PMID 20049410.No evidence for association of the KLF12 gene with rheumatoid arthritis in a large UK cohort. Eyre S, et al. Ann Rheum Dis, 2010 Jul. PMID 19907058.Kr?ppel-like factor 12 plays a significant role in poorly differentiated gastric cancer progression. Nakamura Y, et al. Int J Cancer, 2009 Oct 15. PMID 19588488.
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