KLF12 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9Y4X4 |
Other Accession | O35738, NP_009180.3 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 44240 Da |
Antigen Region | 283-312 aa |
Gene ID | 11278 |
---|---|
Other Names | Krueppel-like factor 12, Transcriptional repressor AP-2rep, KLF12, AP2REP |
Target/Specificity | This KLF12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-312 amino acids from the C-terminal region of human KLF12. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | KLF12 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KLF12 |
---|---|
Synonyms | AP2REP |
Function | Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter. |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Eyre, S., et al. Ann. Rheum. Dis. 69(7):1407-1408(2010)
Wieczorek, S., et al. J. Mol. Med. 88(4):413-421(2010)
Petersen, G.M., et al. Nat. Genet. 42(3):224-228(2010)
Nakamura, Y., et al. Int. J. Cancer 125(8):1859-1867(2009)
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