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KRTHB1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant KRTHB1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF |
|---|---|
| Primary Accession | Q14533 |
| Other Accession | BC021241 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b kappa |
| Clone Names | 3B10-5B10 |
| Calculated MW | 54928 Da |
| Gene ID | 3887 |
|---|---|
| Other Names | Keratin, type II cuticular Hb1, Hair keratin K29, Keratin, hair, basic, Keratin-81, K81, Metastatic lymph node 137 gene protein, MLN 137, Type II hair keratin Hb1, Type-II keratin Kb21, ghHKb1, ghHb1, KRT81, KRTHB1, MLN137 |
| Target/Specificity | KRTHB1 (AAH21241, 1 a.a. ~ 202 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | KRTHB1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.
References
Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.Transcriptional activation of a subset of hair keratin genes by the NF-kappaB effector p65/RelA. Gilon M, et al. Differentiation, 2008 May. PMID 18021261.New consensus nomenclature for mammalian keratins. Schweizer J, et al. J Cell Biol, 2006 Jul 17. PMID 16831889.Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514.Keratins of the human hair follicle. Langbein L, et al. Int Rev Cytol, 2005. PMID 15797458.
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