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MAD2L1BP Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a full-length recombinant MAD2L1BP.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q15013 |
| Other Accession | BC002904 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 4G11 |
| Calculated MW | 31052 Da |
| Gene ID | 9587 |
|---|---|
| Other Names | MAD2L1-binding protein, Caught by MAD2 protein, MAD2L1BP, CMT2, KIAA0110 |
| Target/Specificity | MAD2L1BP (AAH02904, 1 a.a. ~ 274 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | MAD2L1BP Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
References
p31comet Induces cellular senescence through p21 accumulation and Mad2 disruption. Yun M, et al. Mol Cancer Res, 2009 Mar. PMID 19276188.An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904.p31comet blocks Mad2 activation through structural mimicry. Yang M, et al. Cell, 2007 Nov 16. PMID 18022368.Mutation analysis of p31comet gene, a negative regulator of Mad2, in human hepatocellular carcinoma. Yun MY, et al. Exp Mol Med, 2007 Aug 31. PMID 17934339.Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514.
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