NFE2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full-length recombinant NFE2.
|Application ||WB, E|
|Calculated MW||41473 Da|
|Other Names||Transcription factor NF-E2 45 kDa subunit, Leucine zipper protein NF-E2, Nuclear factor, erythroid-derived 2 45 kDa subunit, p45 NF-E2, NFE2|
|Target/Specificity||NFE2 (AAH05044, 1 a.a. ~ 373 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||NFE2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2. Wang W, et al. Blood, 2010 Jul 15. PMID 20339092.USF and NF-E2 cooperate to regulate the recruitment and activity of RNA polymerase II in the beta-globin gene locus. Zhou Z, et al. J Biol Chem, 2010 May 21. PMID 20236933.JNK-mediated turnover and stabilization of the transcription factor p45/NF-E2 during differentiation of murine erythroleukemia cells. Lee TL, et al. Proc Natl Acad Sci U S A, 2010 Jan 5. PMID 19966288.NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation. Motohashi H, et al. Blood, 2010 Jan 21. PMID 19901266.A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Soranzo N, et al. Nat Genet, 2009 Nov. PMID 19820697.
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