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SLC26A4 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant SLC26A4.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | O43511 |
| Other Accession | NM_000441 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3D2 |
| Calculated MW | 85723 Da |
| Gene ID | 5172 |
|---|---|
| Other Names | Pendrin, Sodium-independent chloride/iodide transporter, Solute carrier family 26 member 4, SLC26A4, PDS |
| Target/Specificity | SLC26A4 (NP_000432, 674 a.a. ~ 754 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SLC26A4 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3' of the SLC26A3 gene. The encoded protein has homology to sulfate transporters.
References
Genetic causes of nonsyndromic hearing loss in Iran in comparison with other populations. Mahdieh N, et al. J Hum Genet, 2010 Aug 26. PMID 20739942.Genotyping with a 198 mutation arrayed primer extension array for hereditary hearing loss: assessment of its diagnostic value for medical practice. Rodriguez-Paris J, et al. PLoS One, 2010 Jul 26. PMID 20668687.Screening of SLC26A4, FOXI1 and KCNJ10 genes in unilateral hearing impairment with ipsilateral enlarged vestibular aqueduct. Jonard L, et al. Int J Pediatr Otorhinolaryngol, 2010 Sep. PMID 20621367.Spectrum and frequency of SLC26A4 mutations among Czech patients with early hearing loss with and without Enlarged Vestibular Aqueduct (EVA). Pourov? R, et al. Ann Hum Genet, 2010 Jul. PMID 20597900.Causes of hearing impairment in the Norwegian paediatric cochlear implant program. Siem G, et al. Int J Audiol, 2010 Aug. PMID 20553101.
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