S6A12 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P48065 |
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Other Accession | NP_003035.3, NP_001116320.1, NP_001116319.1 |
Clone Names | 91109044 |
Gene ID | 6539 |
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Other Names | Sodium- and chloride-dependent betaine transporter, BGT-1, Na(+)/Cl(-) betaine/GABA transporter, Solute carrier family 6 member 12, SLC6A12 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SLC6A12 (HGNC:11045) |
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Function | Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process (PubMed:7589472). May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Probably also involved in renal and hepatic osmotic regulation (By similarity). |
Cellular Location | Basolateral cell membrane {ECO:0000250|UniProtKB:P31651}; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:P31651}; Multi-pass membrane protein. Note=In kidney, locates in basolateral membranes of renal medulla. In liver, locates in hepatocytes cell membrane. {ECO:0000250|UniProtKB:P31651} |
Tissue Location | Expressed in kidney, liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.
References
Pasaje, C.F., et al. Ann. Hum. Genet. 74(4):326-334(2010)Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :
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