GSDMC Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BYG8 |
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Clone Names | 91119182 |
Gene ID | 56169 |
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Other Names | Gasdermin-C, Melanoma-derived leucine zipper-containing extranuclear factor, GSDMC, MLZE |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GSDMC {ECO:0000303|PubMed:17350798, ECO:0000312|HGNC:HGNC:7151} |
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Function | [Gasdermin-C]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering pyroptosis. |
Cellular Location | [Gasdermin-C]: Cytoplasm, cytosol |
Tissue Location | Expressed mainly in trachea and spleen (PubMed:11223543). In the esophagus, expressed in differentiating cells and probably in differentiated cells. Also detected in gastric epithelium (PubMed:19051310). |
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Provided below are standard protocols that you may find useful for product applications.
References
Birnbaum, S., et al. Nat. Genet. 41(4):473-477(2009)Saeki, N., et al. Genes Chromosomes Cancer 48(3):261-271(2009)Tamura, M., et al. Genomics 89(5):618-629(2007)Watabe, K., et al. Jpn. J. Cancer Res. 92(2):140-151(2001)
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