CO027 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q2M3C6 |
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Clone Names | 91201152 |
Gene ID | 123591 |
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Other Names | Transmembrane protein C15orf27, C15orf27 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TMEM266 (HGNC:26763) |
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Function | Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum (PubMed:25165868, PubMed:30810529). Despite the presence of a voltage- sensor segment, does not form a functional ion channel and its precise role remains unclear (PubMed:25165868, PubMed:30810529). Undergoes both rapid and slow structural rearrangements in response to changes in voltage (PubMed:30810529). Contains a zinc-binding site that can regulate the slow conformational transition (PubMed:30810529). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Cell projection, dendrite Perikaryon. Note=Present in the dendrites and soma of cerebellar granule neurons, but not in their axon |
Tissue Location | Mainly expressed in the cerebellum (PubMed:25165868). Also expressed in cerebral cortex, skeletal muscle and thyroid, but at much lower levels (PubMed:25165868) |
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Provided below are standard protocols that you may find useful for product applications.
References
Zody, M.C., et al. Nature 440(7084):671-675(2006)
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