NARS Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O43776 |
---|---|
Clone Names | 71228131 |
Gene ID | 4677 |
---|---|
Other Names | Asparagine--tRNA ligase, cytoplasmic, Asparaginyl-tRNA synthetase, AsnRS, NARS |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | NARS1 (HGNC:7643) |
---|---|
Function | Catalyzes the attachment of asparagine to tRNA(Asn) in a two- step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (PubMed:9421509, PubMed:32738225, PubMed:32788587). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells (PubMed:30171954, PubMed:12235211). Has an essential role in the development of the cerebral cortex, being required for proper proliferation of radial glial cells (PubMed:32788587). |
Cellular Location | Cytoplasm. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Aminoacyl-tRNA synthetases are a class of enzymes thatcharge tRNAs with their cognate amino acids. Asparaginyl-tRNAsynthetase is localized to the cytoplasm and belongs to the classII family of tRNA synthetases. The N-terminal domain representsthe signature sequence for the eukaryotic asparaginyl-tRNAsynthetases.
References
Lim, J., et al. Cell 125(4):801-814(2006)Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)Shiba, K., et al. Nucleic Acids Res. 26(22):5045-5051(1998)Beaulande, M., et al. Nucleic Acids Res. 26(2):521-524(1998)Cirullo, R.E., et al. Somatic Cell Genet. 9(2):215-233(1983)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.