Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
IGF2 Antibody (Center R54) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
| Primary Accession | P01344 |
|---|---|
| Clone Names | 80821016 |
| Gene ID | 3481 |
|---|---|
| Other Names | Insulin-like growth factor II, IGF-II, Somatomedin-A, Insulin-like growth factor II, Insulin-like growth factor II Ala-25 Del, Preptin, IGF2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | IGF2 |
|---|---|
| Function | The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity). |
| Cellular Location | Secreted. |
| Tissue Location | Expressed in heart, placenta, lung, liver, muscle, kidney, tongue, limb, eye and pancreas. |
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the insulin family ofpolypeptide growth factors, which are involved in development andgrowth. It is an imprinted gene, expressed only from the paternalallele, and epigenetic changes at this locus are associated withWilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, andSilver-Russell syndrome. A read-through INS-IGF2 gene exists, whose5' region overlaps the INS gene and the 3' region overlaps thisgene. Alternatively spliced transcript variants encoding differentisoforms have been found for this gene.
References
Adkins, R.M., et al. Pediatr. Res. 68(5):429-434(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Li, J., et al. Mol. Biol. Rep. (2010) In press :Hsieh, Y.Y., et al. Anticancer Res. 30(6):2203-2208(2010)Turan, N., et al. PLoS Genet. 6 (7), E1001033 (2010) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
