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PIGA Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P37287 |
|---|---|
| Clone Names | 100318073 |
| Gene ID | 5277 |
|---|---|
| Other Names | Phosphatidylinositol N-acetylglucosaminyltransferase subunit A, GlcNAc-PI synthesis protein, Phosphatidylinositol-glycan biosynthesis class A protein, PIG-A, PIGA |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PIGA (HGNC:8957) |
|---|---|
| Function | Catalytic subunit of the glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein required for synthesis ofN-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the firstintermediate in the biosynthetic pathway of GPI anchor. The GPIanchor is a glycolipid found on many blood cells and which servesto anchor proteins to the cell surface. Paroxysmal nocturnalhemoglobinuria, an acquired hematologic disorder, has been shown toresult from mutations in this gene. Alternate splice variants havebeen characterized. A related pseudogene is located on chromosome12.
References
Borowitz, M.J., et al. Cytometry B Clin Cytom 78(4):211-230(2010)Peruzzi, B., et al. Mutat. Res. 705(1):3-10(2010)Araten, D.J., et al. Mutat. Res. 686 (1-2), 1-8 (2010) :Iida, Y., et al. Blood 83(11):3126-3131(1994)Ware, R.E., et al. Blood 83(9):2418-2422(1994)
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