PEX14 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O75381 |
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Clone Names | 100318088 |
Gene ID | 5195 |
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Other Names | Peroxisomal membrane protein PEX14, PTS1 receptor-docking protein, Peroxin-14, Peroxisomal membrane anchor protein PEX14, PEX14 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PEX14 {ECO:0000303|PubMed:9653144, ECO:0000312|HGNC:HGNC:8856} |
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Function | Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:9653144, PubMed:24235149, PubMed:28765278). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035). |
Cellular Location | Peroxisome membrane; Single-pass membrane protein {ECO:0000250|UniProtKB:Q642G4} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an essential component of theperoxisomal import machinery. The protein is integrated intoperoxisome membranes with its C-terminus exposed to the cytosol,and interacts with the cytosolic receptor for proteins containing aPTS1 peroxisomal targeting signal. The protein also functions as atranscriptional corepressor and interacts with a histonedeacetylase. A mutation in this gene results in one form ofZellweger syndrome.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Macgregor, S., et al. Hum. Mol. Genet. 19(13):2716-2724(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Shiozawa, K., et al. J. Biol. Chem. 284(37):25334-25342(2009)
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