NPTN Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y639 |
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Clone Names | 100405203 |
Gene ID | 27020 |
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Other Names | Neuroplastin, Stromal cell-derived receptor 1, SDR-1, NPTN, SDFR1, SDR1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | NPTN |
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Synonyms | SDFR1, SDR1 |
Function | Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity (PubMed:30190470). Promotes localization of XKR8 at the cell membrane (PubMed:27503893). |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P97546}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P97546} |
Tissue Location | Isoform 1 is ubiquitously expressed. Isoform 2 is expressed in brain cortex and cerebellum (at protein level) {ECO:0000269|PubMed:17196182, ECO:0000269|Ref.1} |
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Background
This gene encodes a type I transmembrane protein belongingto the Ig superfamily. The protein is believed to be involved incell-cell interactions or cell-substrate interactions. Alternativesplicing results in multiple transcript variants. [provided byRefSeq].
References
Bernstein, H.G., et al. Brain Res. 1134(1):107-112(2007)Saito, A., et al. Neurosci. Lett. 411(3):168-173(2007)Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Langnaese, K., et al. J. Biol. Chem. 272(2):821-827(1997)
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