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C9 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P02748 |
|---|---|
| Clone Names | 100430123 |
| Gene ID | 735 |
|---|---|
| Other Names | Complement component C9, Complement component C9a, Complement component C9b, C9 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13782c was selected from the Center region of C9. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | C9 |
|---|---|
| Function | Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells (PubMed:9634479, PubMed:9212048, PubMed:26841934). C9 is the pore-forming subunit of the MAC (PubMed:4055801, PubMed:26841934, PubMed:30111885). |
| Cellular Location | Secreted. Target cell membrane; Multi-pass membrane protein. Note=Secreted as soluble monomer Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore |
| Tissue Location | Plasma (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the final component of the complementsystem. It participates in the formation of the Membrane AttackComplex (MAC). The MAC assembles on bacterial membranes to form apore, permitting disruption of bacterial membrane organization.Mutations in this gene cause component C9 deficiency. [provided byRefSeq].
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)Bunkenborg, J., et al. Proteomics 4(2):454-465(2004)Hofsteenge, J., et al. J. Biol. Chem. 274(46):32786-32794(1999)
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